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Epithelial‐mesenchymal transition via transforming growth factor beta in pancreatic cancer is potentiated by the inflammatory glycoprotein leucine‐rich alpha‐2 glycoprotein

We previously showed that an inflammation‐related, molecule leucine‐rich alpha‐2 glycoprotein (LRG) enhances the transforming growth factor (TGF)‐β1‐induced phosphorylation of Smad proteins and is elevated in patients with pancreatic ductal adenocarcinoma (PDAC). As TGF‐β/Smad signaling is considere...

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Detalles Bibliográficos
Autores principales: Otsuru, Toru, Kobayashi, Shogo, Wada, Hiroshi, Takahashi, Tsuyoshi, Gotoh, Kunihito, Iwagami, Yoshifumi, Yamada, Daisaku, Noda, Takehiro, Asaoka, Tadafumi, Serada, Satoshi, Fujimoto, Minoru, Eguchi, Hidetoshi, Mori, Masaki, Doki, Yuichiro, Naka, Testuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398893/
https://www.ncbi.nlm.nih.gov/pubmed/30575211
http://dx.doi.org/10.1111/cas.13918