Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter

Nramp family transporters—expressed in organisms from bacteria to humans—enable uptake of essential divalent transition metals via an alternating-access mechanism that also involves proton transport. We present high-resolution structures of Deinococcus radiodurans (Dra)Nramp in multiple conformation...

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Detalles Bibliográficos
Autores principales: Bozzi, Aaron T, Zimanyi, Christina M, Nicoludis, John M, Lee, Brandon K, Zhang, Casey H, Gaudet, Rachelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398981/
https://www.ncbi.nlm.nih.gov/pubmed/30714568
http://dx.doi.org/10.7554/eLife.41124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398981/
https://www.ncbi.nlm.nih.gov/pubmed/30714568
http://dx.doi.org/10.7554/eLife.41124

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