Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells

During embryonic development, diffusible signaling molecules called morphogens are thought to determine cell fates in a concentration-dependent way. Yet, in mammalian embryos, concentrations change rapidly compared to the time for making cell fate decisions. Here, we use human embryonic stem cells (...

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Detalles Bibliográficos
Autores principales: Heemskerk, Idse, Burt, Kari, Miller, Matthew, Chhabra, Sapna, Guerra, M Cecilia, Liu, Lizhong, Warmflash, Aryeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398983/
https://www.ncbi.nlm.nih.gov/pubmed/30829572
http://dx.doi.org/10.7554/eLife.40526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6398983/
https://www.ncbi.nlm.nih.gov/pubmed/30829572
http://dx.doi.org/10.7554/eLife.40526

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