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Generalizing a mathematical model of prion aggregation allows strain coexistence and co-stability by including a novel misfolded species

Prions are proteins capable of adopting misfolded conformations and transmitting these conformations to other normally folded proteins. Prions are most commonly known for causing fatal neurodegenerative diseases in mammals but are also associated with several harmless phenotypes in yeast. A distinct...

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Detalles Bibliográficos
Autores principales: Lemarre, Paul, Pujo-Menjouet, Laurent, Sindi, Suzanne S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399074/
https://www.ncbi.nlm.nih.gov/pubmed/30116882
http://dx.doi.org/10.1007/s00285-018-1280-4