Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors

IRE1 is an endoplasmic reticulum (ER) bound transmembrane bifunctional kinase and endoribonuclease protein crucial for the unfolded protein response (UPR) signaling pathway. Upon ER stress, IRE1 homodimerizes, oligomerizes and autophosphorylates resulting in endoribonuclease activity responsible for...

Descripción completa

Detalles Bibliográficos
Autores principales: Carlesso, Antonio, Chintha, Chetan, Gorman, Adrienne M., Samali, Afshin, Eriksson, Leif A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399222/
https://www.ncbi.nlm.nih.gov/pubmed/30833722
http://dx.doi.org/10.1038/s41598-019-39939-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399222/
https://www.ncbi.nlm.nih.gov/pubmed/30833722
http://dx.doi.org/10.1038/s41598-019-39939-z

Ejemplares similares