Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells

IL-2R signaling is essential for regulatory T cell (Treg) function. However, the precise contribution of IL-2 during Treg thymic development, peripheral homeostasis and lineage stability remains unclear. Here we show that IL-2R signaling is required by thymic Tregs at an early step for expansion and...

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Detalles Bibliográficos
Autores principales: Toomer, Kevin H., Lui, Jen Bon, Altman, Norman H., Ban, Yuguang, Chen, Xi, Malek, Thomas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399264/
https://www.ncbi.nlm.nih.gov/pubmed/30833563
http://dx.doi.org/10.1038/s41467-019-08960-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399264/
https://www.ncbi.nlm.nih.gov/pubmed/30833563
http://dx.doi.org/10.1038/s41467-019-08960-1

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