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In vivo investigation of hyperpolarized [1,3-(13)C(2)]acetoacetate as a metabolic probe in normal brain and in glioma
Dysregulation in NAD(+)/NADH levels is associated with increased cell division and elevated levels of reactive oxygen species in rapidly proliferating cancer cells. Conversion of the ketone body acetoacetate (AcAc) to β-hydroxybutyrate (β-HB) by the mitochondrial enzyme β-hydroxybutyrate dehydrogena...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399277/ https://www.ncbi.nlm.nih.gov/pubmed/30833594 http://dx.doi.org/10.1038/s41598-019-39677-2 |