Sustained NF-κB-STAT3 signaling promotes resistance to Smac mimetics in Glioma stem-like cells but creates a vulnerability to EZH2 inhibition

Glioblastoma is an incurable and highly aggressive brain tumor. Understanding therapeutic resistance and survival mechanisms driving this tumor type is key to finding effective therapies. Smac mimetics (SM) emerged as attractive cancer therapeutics particularly for tumor populations that are highly...

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Detalles Bibliográficos
Autores principales: da Hora, Cintia Carla, Pinkham, Kelsey, Carvalho, Litia, Zinter, Max, Tabet, Elie, Nakano, Ichiro, Tannous, Bakhos A., Badr, Christian E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399311/
https://www.ncbi.nlm.nih.gov/pubmed/30854231
http://dx.doi.org/10.1038/s41420-019-0155-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399311/
https://www.ncbi.nlm.nih.gov/pubmed/30854231
http://dx.doi.org/10.1038/s41420-019-0155-9

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