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Molecular constraints on CDR3 for thymic selection of MHC-restricted TCRs from a random pre-selection repertoire
The αβ T cell receptor (TCR) repertoire on mature T cells is selected in the thymus, but the basis for thymic selection of MHC-restricted TCRs from a randomly generated pre-selection repertoire is not known. Here we perform comparative repertoire sequence analyses of pre-selection and post-selection...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399321/ https://www.ncbi.nlm.nih.gov/pubmed/30833553 http://dx.doi.org/10.1038/s41467-019-08906-7 |