Cargando…

Hedgehog signaling in the airway epithelium of patients with chronic obstructive pulmonary disease

Genome-wide association studies have linked gene variants of the receptor patched homolog 1 (PTCH1) with chronic obstructive pulmonary disease (COPD). However, its biological role in the disease is unclear. Our objective was to determine the expression pattern and biological role of PTCH1 in the lun...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tam, A., Hughes, M., McNagny, K. M., Obeidat, M., Hackett, T. L., Leung, J. M., Shaipanich, T., Dorscheid, D. R., Singhera, G. K., Yang, C. W. T., Paré, P. D., Hogg, J. C., Nickle, D., Sin, D. D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399332/ https://www.ncbi.nlm.nih.gov/pubmed/30833624 http://dx.doi.org/10.1038/s41598-019-40045-3

Ejemplares similares

Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma
por: Tam, Anthony, et al.
Publicado: (2022)

ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19
por: Leung, Janice M., et al.
Publicado: (2020)

Expression of surfactant protein D in airways of asthmatics and interleukin-13 modulation of surfactant protein D in human models of airway epithelium
por: Xu, Jie, et al.
Publicado: (2015)

Olodaterol exerts anti-inflammatory effects on COPD airway epithelial cells
por: Yang, Nan, et al.
Publicado: (2021)

Airway Epithelial-Derived Immune Mediators in COVID-19
por: Guo, Tony J. F., et al.
Publicado: (2023)

Inhaled Corticosteroids Selectively Alter the Microbiome and Host Transcriptome in the Small Airways of Patients with Chronic Obstructive Pulmonary Disease
por: Yip, William, et al.
Publicado: (2022)

Decreased microbiome diversity in the HIV small airway epithelium
por: Xu, Stella, et al.
Publicado: (2018)

Decreased telomere length in the small airway epithelium suggests accelerated aging in the lungs of persons living with human immunodeficiency virus (HIV)
por: Xu, Stella, et al.
Publicado: (2018)

Widespread Sexual Dimorphism in the Transcriptome of Human Airway Epithelium in Response to Smoking
por: Yang, Chen Xi, et al.
Publicado: (2019)

Co-exposure to allergen and diesel exhaust enhance inflammatory responses in human airway submucosa
por: Hosseini, Ali, et al.
Publicado: (2014)

Lineage specific role of Ship1 in development of allergic airway inflammation
por: Gold, Matthew J, et al.
Publicado: (2014)

Refining Susceptibility Loci of Chronic Obstructive Pulmonary Disease with Lung eqtls
por: Lamontagne, Maxime, et al.
Publicado: (2013)

IL-4Rα blockade reduces influenza-associated morbidity in a murine model of allergic asthma
por: Shahangian, Kimia, et al.
Publicado: (2021)

IL-13Rα2/AP-1 complex signalling mediates airway epithelial repair without effects on remodeling pathways
por: Yang, Jasemine S, et al.
Publicado: (2010)

Interactions of oxygen radicals with airway epithelium.
por: Wright, D T, et al.
Publicado: (1994)

Apoptosis of viral-infected airway epithelial cells limit viral production and is altered by corticosteroid exposure
por: Singhera, Gurpreet K, et al.
Publicado: (2006)

Transcriptomic and proteomic host response to Aspergillus fumigatus conidia in an air-liquid interface model of human bronchial epithelium
por: Toor, Amreen, et al.
Publicado: (2018)

Analysis of Tie2 function in mast cells
por: Hirukawa, Alison, et al.
Publicado: (2010)

Responsiveness to Ipratropium Bromide in Male and Female Patients with Mild to Moderate Chronic Obstructive Pulmonary Disease
por: Li, Xuan, et al.
Publicado: (2017)

Clinical update on the use of biomarkers of airway inflammation in the management of asthma
por: Wadsworth, SJ, et al.
Publicado: (2011)

Sex differences in lymphoid follicles in COPD airways
por: Tam, Anthony, et al.
Publicado: (2020)

Macrophages with reduced expressions of classical M1 and M2 surface markers in human bronchoalveolar lavage fluid exhibit pro-inflammatory gene signatures
por: Takiguchi, Hiroto, et al.
Publicado: (2021)

CD34 is required for the infiltration of inflammatory cells into the mouse colon during DSS-induced colitis
por: Maltby, Steven, et al.
Publicado: (2010)

Stem cells, inflammation and allergy
por: Blanchet, Marie-Renee, et al.
Publicado: (2009)

ILC-You in the Thymus: A Fresh Look at Innate Lymphoid Cell Development
por: Shin, Samuel B., et al.
Publicado: (2021)

Surface Molecules Involved in Avian T-Cell Progenitor Migration and Differentiation
por: Ody, C., et al.
Publicado: (2000)

Expression of Myoferlin in Human Airway Epithelium and Its Role in Cell Adhesion and Zonula Occludens-1 Expression
por: Leung, Cleo, et al.
Publicado: (2012)

“Just one word, plastic!”: Controversies and caveats in innate lymphoid cell plasticity
por: Kabil, Ahmed, et al.
Publicado: (2022)

Making Eosinophils Through Subtle Shifts in Transcription Factor Expression
por: McNagny, Kelly, et al.
Publicado: (2002)

Cellular and functional heterogeneity of the airway epithelium
por: Davis, Jordan D., et al.
Publicado: (2021)

Morphometric analysis of inflammation in bronchial biopsies following exposure to inhaled diesel exhaust and allergen challenge in atopic subjects
por: Hosseini, Ali, et al.
Publicado: (2016)

Engineering Airway Epithelium
por: Soleas, John P., et al.
Publicado: (2012)

The Overlap of Lung Tissue Transcriptome of Smoke Exposed Mice with Human Smoking and COPD
por: Obeidat, Ma’en, et al.
Publicado: (2018)

Correction: Cellular and functional heterogeneity of the airway epithelium
por: Davis, Jordan D., et al.
Publicado: (2022)

Platelet signaling at the nexus of innate immunity and rheumatoid arthritis
por: Jiang, Steven Z., et al.
Publicado: (2022)

Smoking accelerates aging of the small airway epithelium
por: Walters, Matthew S, et al.
Publicado: (2014)

A Brief History of Airway Smooth Muscle's Role in Airway Hyperresponsiveness
por: Pascoe, C. D., et al.
Publicado: (2012)

Systemic and Airway Epigenetic Disruptions Are Associated with Health Status in COPD
por: Hernandez Cordero, Ana I., et al.
Publicado: (2023)

The role of reactive oxygen and nitrogen species in the response of airway epithelium to particulates.
por: Martin, L D, et al.
Publicado: (1997)

Interaction between hedgehog signalling and PAX6 dosage mediates maintenance and regeneration of the corneal epithelium
por: Kucerova, Romana, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_ek4kte6n7uusisj05j6rp1cn4f