Synthetic energy sensor AMPfret deciphers adenylate-dependent AMPK activation mechanism

AMP-activated protein kinase AMPK senses and regulates cellular energy state. AMPK activation by increasing AMP and ADP concentrations involves a conformational switch within the heterotrimeric complex. This is exploited here for the construction of a synthetic sensor of cellular energetics and allo...

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Detalles Bibliográficos
Autores principales: Pelosse, Martin, Cottet-Rousselle, Cécile, Bidan, Cécile M., Dupont, Aurélie, Gupta, Kapil, Berger, Imre, Schlattner, Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399333/
https://www.ncbi.nlm.nih.gov/pubmed/30833561
http://dx.doi.org/10.1038/s41467-019-08938-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399333/
https://www.ncbi.nlm.nih.gov/pubmed/30833561
http://dx.doi.org/10.1038/s41467-019-08938-z

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