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Exploring Impact of Rare Variation in Systemic Lupus Erythematosus by a Genome Wide Imputation Approach

The importance of low frequency and rare variation in complex disease genetics is difficult to estimate in patient populations. Genome-wide association studies are therefore, underpowered to detect rare variation. We have used a combined approach of genome-wide-based imputation with a highly stringe...

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Detalles Bibliográficos
Autores principales: Martínez-Bueno, Manuel, Alarcón-Riquelme, Marta E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399402/
https://www.ncbi.nlm.nih.gov/pubmed/30863397
http://dx.doi.org/10.3389/fimmu.2019.00258