FcγR-Binding Is an Important Functional Attribute for Immune Checkpoint Antibodies in Cancer Immunotherapy

T cells play critical roles in anti-tumor immunity. Up-regulation of immune checkpoint molecules (PD-1, PD-L1, CTLA-4, TIM-3, Lag-3, TIGIT, CD73, VISTA, B7-H3) in the tumor microenvironment is an important mechanism that restrains effector T cells from the anti-tumor activity. To date, immune checkp...

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Detalles Bibliográficos
Autores principales: Chen, Xin, Song, Xiaomin, Li, Kang, Zhang, Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399403/
https://www.ncbi.nlm.nih.gov/pubmed/30863404
http://dx.doi.org/10.3389/fimmu.2019.00292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399403/
https://www.ncbi.nlm.nih.gov/pubmed/30863404
http://dx.doi.org/10.3389/fimmu.2019.00292

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