Regulation of BRAF protein stability by a negative feedback loop involving the MEK–ERK pathway but not the FBXW7 tumour suppressor

The (V600E)BRAF oncogenic mutation is detected in a wide range of human cancers and induces hyperactivation of the downstream MEK–ERK signalling cascade. Although output of the BRAF–MEK–ERK pathway is regulated by feed-forward RAF activity, feedback control also plays an important role. One such fee...

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Detalles Bibliográficos
Autores principales: Hernandez, Maria Aguilar, Patel, Bipin, Hey, Fiona, Giblett, Susan, Davis, Hayley, Pritchard, Catrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399479/
https://www.ncbi.nlm.nih.gov/pubmed/26898828
http://dx.doi.org/10.1016/j.cellsig.2016.02.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399479/
https://www.ncbi.nlm.nih.gov/pubmed/26898828
http://dx.doi.org/10.1016/j.cellsig.2016.02.009

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