Cargando…

Detection of Alzheimer’s disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau)

Pathological tau aggregates in Alzheimer’s disease (AD) and frontotemporal lobar degeneration-tau (FTLD-tau) adopt distinct conformations differentiated by the AD-tau specific monoclonal antibody (mAb) GT-38 that are not readily visualized using phosphorylation-specific anti-tau mAbs. To determine t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gibbons, Garrett S., Kim, Soo-Jung, Robinson, John L., Changolkar, Lakshmi, Irwin, David J., Shaw, Leslie M., Lee, Virginia M.-Y., Trojanowski, John Q.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399892/ https://www.ncbi.nlm.nih.gov/pubmed/30832741 http://dx.doi.org/10.1186/s40478-019-0687-5

Ejemplares similares

Tau immunotherapy is associated with glial responses in FTLD-tau
por: Kim, Boram, et al.
Publicado: (2021)

Tau physiology and pathomechanisms in frontotemporal lobar degeneration
por: Bodea, Liviu‐Gabriel, et al.
Publicado: (2016)

Conformation-selective tau monoclonal antibodies inhibit tau pathology in primary neurons and a mouse model of Alzheimer’s disease
por: Gibbons, Garrett S., et al.
Publicado: (2020)

Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration
por: Giannini, Lucia A. A., et al.
Publicado: (2022)

Correction to: Isoform-specific patterns of tau burden and neuronal degeneration in MAPT-associated frontotemporal lobar degeneration
por: Giannini, Lucia A. A., et al.
Publicado: (2023)

Concurrent tau pathologies in frontotemporal lobar degeneration with TDP‐43 pathology
por: Koga, Shunsuke, et al.
Publicado: (2021)

Event-based modeling of T1-weighted MRI is related to pathology in frontotemporal lobar degeneration due to tau and TDP
por: Olm, Christopher A., et al.
Publicado: (2022)

Human tau pathology transmits glial tau aggregates in the absence of neuronal tau
por: Narasimhan, Sneha, et al.
Publicado: (2019)

Unique pathological tau conformers from Alzheimer’s brains transmit tau pathology in nontransgenic mice
por: Guo, Jing L., et al.
Publicado: (2016)

FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration
por: Urwin, Hazel, et al.
Publicado: (2010)

Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration
por: Thijssen, Elisabeth H., et al.
Publicado: (2020)

Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations()
por: Rohrer, Jonathan D., et al.
Publicado: (2010)

Frontotemporal lobar degeneration: old knowledge and new insight into the pathogenetic mechanisms of tau mutations
por: Rossi, Giacomina, et al.
Publicado: (2015)

Diagnostic value of cerebrospinal fluid tau, neurofilament, and progranulin in definite frontotemporal lobar degeneration
por: Goossens, Joery, et al.
Publicado: (2018)

Comparative assessment of regional tau distribution by Tau-PET and Post-mortem neuropathology in a representative set of Alzheimer’s & frontotemporal lobar degeneration patients
por: Gatto, Rodolfo G., et al.
Publicado: (2023)

Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s disease and frontotemporal lobar degeneration
por: Cranston, Anna L, et al.
Publicado: (2020)

Pathological tau deposition in Motor Neurone Disease and frontotemporal lobar degeneration associated with TDP-43 proteinopathy
por: Behrouzi, Roya, et al.
Publicado: (2016)

Ex vivo MRI and histopathology detect novel iron-rich cortical inflammation in frontotemporal lobar degeneration with tau versus TDP-43 pathology
por: Tisdall, M. Dylan, et al.
Publicado: (2021)

β-Arrestin2 arrests the clearance of tau in FTLD
por: Thathiah, Amantha
Publicado: (2020)

Retina tissue validation of optical coherence tomography determined outer nuclear layer loss in FTLD-tau
por: Kim, Benjamin J., et al.
Publicado: (2021)

Fyn nanoclustering requires switching to an open conformation and is enhanced by FTLD-Tau biomolecular condensates
por: Martínez-Mármol, Ramón, et al.
Publicado: (2022)

Clinical value of neurofilament and phospho-tau/tau ratio in the frontotemporal dementia spectrum
por: Meeter, Lieke H.H., et al.
Publicado: (2018)

Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants
por: Lin, Li-Chun, et al.
Publicado: (2019)

Tau-focused therapy and tau transmission: Implications for Alzheimer’s Disease and related tauopathies
por: Trojanowski, John Q
Publicado: (2013)

LRRK2 Kinase Activity Does Not Alter Cell-Autonomous Tau Pathology Development in Primary Neurons
por: Henderson, Michael X., et al.
Publicado: (2021)

Optimum Differentiation of Frontotemporal Lobar Degeneration from Alzheimer Disease Achieved with Cross‐Sectional Tau Positron Emission Tomography
por: Josephs, Keith A., et al.
Publicado: (2022)

Plasma tau is increased in frontotemporal dementia
por: Foiani, Martha S, et al.
Publicado: (2018)

Updated Measurement of the \tau Polarisation in \tau -> \tau(K)\nu_\tau
por: Moraes, D, et al.
Publicado: (1998)

In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics
por: Xu, Hong, et al.
Publicado: (2021)

Evaluation of Plasma Phosphorylated Tau217 for Differentiation Between Alzheimer Disease and Frontotemporal Lobar Degeneration Subtypes Among Patients With Corticobasal Syndrome
por: VandeVrede, Lawren, et al.
Publicado: (2023)

Reduced Tau protein expression is associated with frontotemporal degeneration with progranulin mutation
por: Papegaey, Anthony, et al.
Publicado: (2016)

Search for the decays $B_s^0\to\tau^+\tau^-$ and $B^0\to\tau^+\tau^-$
por: Aaij, Roel, et al.
Publicado: (2017)

Axonal Degeneration in AD: The Contribution of Aβ and Tau
por: Salvadores, Natalia, et al.
Publicado: (2020)

Measurement of sigma_tau+ tau- and A^tau+ tau- _FB with '92 data
por: Ganis, G, et al.
Publicado: (1994)

$Z \to \tau\tau$ and $W \to \tau\nu_\tau$ Cross-Sections at the LHC
por: Ilten, Philip
Publicado: (2012)

Delusion of Pregnancy in Frontotemporal Lobar Degeneration with Motor Neurone Disease (FTLD/MND)
por: Larner, A. J.
Publicado: (2008)

PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding
por: Soares, Alberto Carpinteiro, et al.
Publicado: (2021)

Tau at CMS (From Tau Lepton and Tau in SM measurements to Tau Role in Discovery)
por: Mohammadi, Abdollah
Publicado: (2012)

Host Tau Genotype Specifically Designs and Regulates Tau Seeding and Spreading and Host Tau Transformation Following Intrahippocampal Injection of Identical Tau AD Inoculum
por: Andrés-Benito, Pol, et al.
Publicado: (2022)

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody
por: Luo, Wenjie, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_uerb5fakt56jeh0r8t4885iv25