The ‘Achilles Heel’ of Metabolism in Renal Cell Carcinoma: Glutaminase Inhibition as a Rational Treatment Strategy

An important hallmark of cancer is ‘metabolic reprogramming’ or the rewiring of cellular metabolism to support rapid cell proliferation [1–5]. Metabolic reprogramming through oncometabolite-mediated transformation or activation of oncogenes in renal cell carcinoma (RCC) globally impacts energy produ...

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Detalles Bibliográficos
Autores principales: Hoerner, Christian R., Chen, Viola J., Fan, Alice C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400133/
https://www.ncbi.nlm.nih.gov/pubmed/30854496
http://dx.doi.org/10.3233/KCA-180043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400133/
https://www.ncbi.nlm.nih.gov/pubmed/30854496
http://dx.doi.org/10.3233/KCA-180043

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