A cytosine modification mechanism revealed by the structure of a ternary complex of deoxycytidylate hydroxymethylase from bacteriophage T4 with its cofactor and substrate

To protect viral DNA against the host bacterial restriction system, bacterio­phages utilize a special modification system – hydroxymethylation – in which dCMP hydroxymethylase (dCH) converts dCMP to 5-hydroxymethyl-dCMP (5hm-dCMP) using N5,N10-methylenetetrahydrofolate as a cofactor. Despite shared...

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Detalles Bibliográficos
Autores principales: Park, Si Hoon, Suh, Se Won, Song, Hyun Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2019
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400193/
https://www.ncbi.nlm.nih.gov/pubmed/30867918
http://dx.doi.org/10.1107/S2052252518018274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400193/
https://www.ncbi.nlm.nih.gov/pubmed/30867918
http://dx.doi.org/10.1107/S2052252518018274

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