Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells

Cancer models based on cells derived from human embryonic stem cells (hESCs) may reveal why certain constellations of genetic changes drive carcinogenesis in specialized lineages. Here we demonstrate that inhibition of NOTCH signaling induces up to 10% of lung progenitor cells to form pulmonary neur...

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Detalles Bibliográficos
Autores principales: Chen, Huanhuan Joyce, Poran, Asaf, Unni, Arun M., Huang, Sarah Xuelian, Elemento, Olivier, Snoeck, Hans-Willem, Varmus, Harold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400536/
https://www.ncbi.nlm.nih.gov/pubmed/30737256
http://dx.doi.org/10.1084/jem.20181155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400536/
https://www.ncbi.nlm.nih.gov/pubmed/30737256
http://dx.doi.org/10.1084/jem.20181155

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