Cargando…

Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells

Cancer models based on cells derived from human embryonic stem cells (hESCs) may reveal why certain constellations of genetic changes drive carcinogenesis in specialized lineages. Here we demonstrate that inhibition of NOTCH signaling induces up to 10% of lung progenitor cells to form pulmonary neur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Huanhuan Joyce, Poran, Asaf, Unni, Arun M., Huang, Sarah Xuelian, Elemento, Olivier, Snoeck, Hans-Willem, Varmus, Harold
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400536/ https://www.ncbi.nlm.nih.gov/pubmed/30737256 http://dx.doi.org/10.1084/jem.20181155

Ejemplares similares

FORMATION OF MALIGNANT, METASTATIC SMALL CELL LUNG CANCERS THROUGH OVERPRODUCTION OF cMYC PROTEIN IN TP53 AND RB1 DEPLETED PULMONARY NEUROENDOCRINE CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS
por: Chen, Huanhuan Joyce, et al.
Publicado: (2023)

Single-cell TCRseq: paired recovery of entire T-cell alpha and beta chain transcripts in T-cell receptors from single-cell RNAseq
por: Redmond, David, et al.
Publicado: (2016)

Lineage Plasticity in SCLC Generates Non-Neuroendocrine Cells Primed for Vasculogenic Mimicry
por: Pearsall, Sarah M., et al.
Publicado: (2023)

Non-neuroendocrine differentiation generates a ferroptosis-prone lipidome in small cell lung cancer (SCLC)
por: Bebber, Christina M., et al.
Publicado: (2021)

Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes
por: Bebber, Christina M., et al.
Publicado: (2021)

Is transformed small cell lung cancer (SCLC) different from de novo SCLC?
por: Park, Cheol-Kyu, et al.
Publicado: (2019)

Clinicopathological Difference and Survival Impact of Patients with c-SCLC and SCLC
por: Zhang, Chenyue, et al.
Publicado: (2021)

Novel Mouse Cell Lines and In Vivo Models for Human High-Grade Neuroendocrine Lung Carcinoma, Small Cell Lung Carcinoma (SCLC), and Large Cell Neuroendocrine Carcinoma (LCNEC)
por: Recuero, Enrique, et al.
Publicado: (2023)

Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells
por: Unni, Arun M, et al.
Publicado: (2018)

Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma
por: Unni, Arun M, et al.
Publicado: (2015)

Sonic Hedgehog in SCLC
por: Laukkanen, Mikko O., et al.
Publicado: (2015)

Pathology and Classification of SCLC
por: Raso, Maria Gabriela, et al.
Publicado: (2021)

Revisiting the initial steps of sexual development in the malaria parasite Plasmodium falciparum
por: Bancells, Cristina, et al.
Publicado: (2018)

Promising Role of Circulating Tumor Cells in the Management of SCLC
por: De Luca, Antonella, et al.
Publicado: (2021)

What Are the Biomarkers for Immunotherapy in SCLC?
por: Longo, Vito, et al.
Publicado: (2021)

Prophylactic cranial irradiation in SCLC
por: Suwinski, Rafal
Publicado: (2021)

What's New in SCLC? A Review
por: Oronsky, Bryan, et al.
Publicado: (2017)

Understanding SCLC heterogeneity and plasticity in cancer metastasis and chemotherapy resistance: Understanding SCLC heterogeneity and plasticity in metastasis and chemoresistance
por: Jin, Yujuan, et al.
Publicado: (2023)

Development and Validation of a Simplified Prognostic Score in SCLC
por: Negre, Elodie, et al.
Publicado: (2020)

Update on the Biology, Management, and Treatment of Small Cell Lung Cancer (SCLC)
por: Saltos, Andreas, et al.
Publicado: (2020)

EGFR-Mutated Lung Adenocarcinoma Successfully Treated With Osimertinib After Spontaneous Transformation to SCLC and Adenocarcinoma With Neuroendocrine Differentiation: Case Report
por: Takuma, Sho, et al.
Publicado: (2021)

Developmental heterogeneity of embryonic neuroendocrine chromaffin cells and their maturation dynamics
por: Akkuratova, Natalia, et al.
Publicado: (2022)

SCLC-J1, a novel small cell lung cancer cell line
por: Ohara, Kazuo, et al.
Publicado: (2021)

Third-Generation TKI Resistance Due to SCLC Transformation: A Case Report and Brief Review
por: Chen, Shen, et al.
Publicado: (2019)

Durvalumab: A Review in Extensive-Stage SCLC
por: Al-Salama, Zaina T.
Publicado: (2021)

Arginine Deprivation in SCLC: Mechanisms and Perspectives for Therapy
por: Carpentier, Joséphine, et al.
Publicado: (2022)

Impact of Socioeconomic Factors on Overall Survival in SCLC
por: Roof, Logan, et al.
Publicado: (2022)

Genes and the biology of cancer /
por: Varmus, Harold
Publicado: (1993)

Progress toward Public Access to Science
por: Varmus, Harold
Publicado: (2008)

Of oncogenes and open science: an interview with Harold Varmus
por: Varmus, Harold
Publicado: (2019)

Small Cell Lung Cancer (SCLC) Presenting as Acute Pancreatitis: The Role of Hypercalcemia
por: Tan, Jessica, et al.
Publicado: (2012)

A 2022 Update on Extensive Stage Small-Cell Lung Cancer (SCLC)
por: Oronsky, Bryan, et al.
Publicado: (2022)

Activation of PyMT in β Cells Induces Irreversible Hyperplasia, but Oncogene-Dependent Acinar Cell Carcinomas When Activated in Pancreatic Progenitors
por: Du, Yi-Chieh Nancy, et al.
Publicado: (2009)

Next-Generation Sequencing in Lung Cancer Patients: A Comparative Approach in NSCLC and SCLC Mutational Landscapes
por: Pop-Bica, Cecilia, et al.
Publicado: (2022)

Serum neuron-specific enolase (S-NSE) in progressive small-cell lung cancer (SCLC).
por: Jørgensen, L. G., et al.
Publicado: (1994)

The role of postoperative radiotherapy (PORT) in combined small cell lung cancer (C-SCLC)
por: Men, Yu, et al.
Publicado: (2017)

Clinical characteristics and patient outcomes of molecular subtypes of small cell lung cancer (SCLC)
por: Ding, Xiao-Long, et al.
Publicado: (2022)

Could Somatostatin Enhance the Outcomes of Chemotherapeutic Treatment in SCLC?
por: Domvri, Kalliopi, et al.
Publicado: (2015)

Correction to: Durvalumab: A Review in Extensive-Stage SCLC
por: Al-Salama, Zaina T.
Publicado: (2021)

Organoids as a Systems Platform for SCLC Brain Metastasis
por: Quaranta, Vito, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4jther58do83qk0j6tkuh7dsom