Multi-color lineage tracing reveals clonal dynamics of squamous carcinoma evolution from initiation to metastasis

Tumor cells are subjected to evolutionary selection pressures during progression from initiation to metastasis. We analyzed the clonal evolution of squamous skin carcinomas induced by DMBA/TPA treatment using the K5CreER-Confetti mouse and stage-specific lineage tracing. We show that benign tumors a...

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Detalles Bibliográficos
Autores principales: Reeves, Melissa Q., Kandyba, Eve, Harris, Sophie, Del Rosario, Reyno, Balmain, Allan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400587/
https://www.ncbi.nlm.nih.gov/pubmed/29802408
http://dx.doi.org/10.1038/s41556-018-0109-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400587/
https://www.ncbi.nlm.nih.gov/pubmed/29802408
http://dx.doi.org/10.1038/s41556-018-0109-0

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