The use of technical replication for detection of low-level somatic mutations in next-generation sequencing

Accurate genome-wide detection of somatic mutations with low variant allele frequency (VAF, <1%) has proven difficult, for which generalized, scalable methods are lacking. Herein, we describe a new computational method, called RePlow, that we developed to detect low-VAF somatic mutations based on...

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Detalles Bibliográficos
Autores principales: Kim, Junho, Kim, Dachan, Lim, Jae Seok, Maeng, Ju Heon, Son, Hyeonju, Kang, Hoon-Chul, Nam, Hojung, Lee, Jeong Ho, Kim, Sangwoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400950/
https://www.ncbi.nlm.nih.gov/pubmed/30837471
http://dx.doi.org/10.1038/s41467-019-09026-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400950/
https://www.ncbi.nlm.nih.gov/pubmed/30837471
http://dx.doi.org/10.1038/s41467-019-09026-y

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