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Vegfa/vegfr2 signaling is necessary for zebrafish islet vessel development, but is dispensable for beta-cell and alpha-cell formation

The mechanisms underlying zebrafish pancreatic islet vascularization have not been well characterized. We sought to determine the angiogenic factors responsible for islet vascularization and assess whether an absence of endothelial cells affects beta-cell and alpha-cell formation. We used a double t...

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Detalles Bibliográficos
Autores principales: Toselli, Chiara M., Wilkinson, Brayden M., Paterson, Joshua, Kieffer, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401103/
https://www.ncbi.nlm.nih.gov/pubmed/30837605
http://dx.doi.org/10.1038/s41598-019-40136-1