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Loss of a proteostatic checkpoint in intestinal stem cells contributes to age-related epithelial dysfunction
A decline in protein homeostasis (proteostasis) has been proposed as a hallmark of aging. Somatic stem cells (SCs) uniquely maintain their proteostatic capacity through mechanisms that remain incompletely understood. Here, we describe and characterize a ‘proteostatic checkpoint’ in Drosophila intest...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401111/ https://www.ncbi.nlm.nih.gov/pubmed/30837466 http://dx.doi.org/10.1038/s41467-019-08982-9 |