CRISPR/Cas9 targeted CAPTURE of mammalian genomic regions for characterization by NGS

The robust detection of structural variants in mammalian genomes remains a challenge. It is particularly difficult in the case of genetically unstable Chinese hamster ovary (CHO) cell lines with only draft genome assemblies available. We explore the potential of the CRISPR/Cas9 system for the target...

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Detalles Bibliográficos
Autores principales: Slesarev, Alexei, Viswanathan, Lakshmi, Tang, Yitao, Borgschulte, Trissa, Achtien, Katherine, Razafsky, David, Onions, David, Chang, Audrey, Cote, Colette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401131/
https://www.ncbi.nlm.nih.gov/pubmed/30837529
http://dx.doi.org/10.1038/s41598-019-39667-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401131/
https://www.ncbi.nlm.nih.gov/pubmed/30837529
http://dx.doi.org/10.1038/s41598-019-39667-4

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