ALDH1A1 regulates postsynaptic μ–opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling

Aldehyde dehydrogenase 1A1 (ALDH1A1), a retinoic acid (RA) synthase, is selectively expressed by the nigrostriatal dopaminergic (nDA) neurons that preferentially degenerate in Parkinson’s disease (PD). ALDH1A1–positive axons mainly project to the dorsal striatum. However, whether ALDH1A1 and its pro...

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Detalles Bibliográficos
Autores principales: Pan, Jing, Yu, Jia, Sun, Lixin, Xie, Chengsong, Chang, Lisa, Wu, Junbing, Hawes, Sarah, Saez–Atienzar, Sara, Zheng, Wang, Kung, Justin, Ding, Jinhui, Le, Weidong, Chen, Shengdi, Cai, Huaibin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401150/
https://www.ncbi.nlm.nih.gov/pubmed/30837649
http://dx.doi.org/10.1038/s41598-019-40326-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401150/
https://www.ncbi.nlm.nih.gov/pubmed/30837649
http://dx.doi.org/10.1038/s41598-019-40326-x

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