Unexpected genomic rearrangements at targeted loci associated with CRISPR/Cas9-mediated knock-in

The CRISPR/Cas9 gene editing tool enables accessible and efficient modifications which (re)ignited molecular research in certain species. However, targeted integration of large DNA fragments using CRISPR/Cas9 can still be challenging in numerous models. To systematically compare CRISPR/Cas9’s effici...

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Detalles Bibliográficos
Autores principales: Rezza, Amélie, Jacquet, Christelle, Le Pillouer, Amélie, Lafarguette, Florian, Ruptier, Charlotte, Billandon, Marion, Isnard Petit, Patricia, Trouttet, Séverine, Thiam, Kader, Fraichard, Alexandre, Chérifi, Yacine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401152/
https://www.ncbi.nlm.nih.gov/pubmed/30837594
http://dx.doi.org/10.1038/s41598-019-40181-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401152/
https://www.ncbi.nlm.nih.gov/pubmed/30837594
http://dx.doi.org/10.1038/s41598-019-40181-w

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