Ca(2+)/Calmodulin-Dependent Protein Kinase II (CaMKII) β-Dependent Phosphorylation of GABA(B1) Triggers Lysosomal Degradation of GABA(B) Receptors via Mind Bomb-2 (MIB2)-Mediated Lys-63-Linked Ubiquitination

The G protein-coupled GABA(B) receptors, constituted from GABA(B1) and GABA(B2) subunits, are important regulators of neuronal excitability by mediating long-lasting inhibition. One factor that determines receptor availability and thereby the strength of inhibition is regulated protein degradation....

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Detalles Bibliográficos
Autores principales: Zemoura, Khaled, Balakrishnan, Karthik, Grampp, Thomas, Benke, Dietmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401210/
https://www.ncbi.nlm.nih.gov/pubmed/29881949
http://dx.doi.org/10.1007/s12035-018-1142-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401210/
https://www.ncbi.nlm.nih.gov/pubmed/29881949
http://dx.doi.org/10.1007/s12035-018-1142-5

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