Cargando…
Ca(2+)/Calmodulin-Dependent Protein Kinase II (CaMKII) β-Dependent Phosphorylation of GABA(B1) Triggers Lysosomal Degradation of GABA(B) Receptors via Mind Bomb-2 (MIB2)-Mediated Lys-63-Linked Ubiquitination
The G protein-coupled GABA(B) receptors, constituted from GABA(B1) and GABA(B2) subunits, are important regulators of neuronal excitability by mediating long-lasting inhibition. One factor that determines receptor availability and thereby the strength of inhibition is regulated protein degradation....
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer US
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401210/ https://www.ncbi.nlm.nih.gov/pubmed/29881949 http://dx.doi.org/10.1007/s12035-018-1142-5 |