Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression

While genetic variation at chromatin loops is relevant for human disease, the relationships between contact propensity (the probability that loci at loops physically interact), genetics, and gene regulation are unclear. We quantitatively interrogate these relationships by comparing Hi-C and molecula...

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Detalles Bibliográficos
Autores principales: Greenwald, William W., Li, He, Benaglio, Paola, Jakubosky, David, Matsui, Hiroko, Schmitt, Anthony, Selvaraj, Siddarth, D’Antonio, Matteo, D’Antonio-Chronowska, Agnieszka, Smith, Erin N., Frazer, Kelly A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401380/
https://www.ncbi.nlm.nih.gov/pubmed/30837461
http://dx.doi.org/10.1038/s41467-019-08940-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401380/
https://www.ncbi.nlm.nih.gov/pubmed/30837461
http://dx.doi.org/10.1038/s41467-019-08940-5

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