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Immunotherapeutic Targeting of GPC3 in Pediatric Solid Embryonal Tumors

Glypican 3 (GPC3) is a heparan sulfate proteoglycan and cell surface oncofetal protein which is highly expressed on a variety of pediatric solid embryonal tumors including the majority of hepatoblastomas, Wilms tumors, rhabdoid tumors, certain germ cell tumor subtypes, and a minority of rhabdomyosar...

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Detalles Bibliográficos
Autores principales: Ortiz, Michael V., Roberts, Stephen S., Glade Bender, Julia, Shukla, Neerav, Wexler, Leonard H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6401603/
https://www.ncbi.nlm.nih.gov/pubmed/30873384
http://dx.doi.org/10.3389/fonc.2019.00108