Assessing correlates of protection in vaccine trials: statistical solutions in the context of high vaccine efficacy

BACKGROUND: The use of correlates of protection (CoPs) in vaccination trials offers significant advantages as useful clinical endpoint substitutes. Vaccines with very high vaccine efficacy (VE) are documented in the literature (VE ≥95%). The rare events (number of infections) observed in the vaccina...

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Detalles Bibliográficos
Autores principales: Callegaro, Andrea, Tibaldi, Fabian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402125/
https://www.ncbi.nlm.nih.gov/pubmed/30841856
http://dx.doi.org/10.1186/s12874-019-0687-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402125/
https://www.ncbi.nlm.nih.gov/pubmed/30841856
http://dx.doi.org/10.1186/s12874-019-0687-y

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