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Assessing correlates of protection in vaccine trials: statistical solutions in the context of high vaccine efficacy
BACKGROUND: The use of correlates of protection (CoPs) in vaccination trials offers significant advantages as useful clinical endpoint substitutes. Vaccines with very high vaccine efficacy (VE) are documented in the literature (VE ≥95%). The rare events (number of infections) observed in the vaccina...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402125/ https://www.ncbi.nlm.nih.gov/pubmed/30841856 http://dx.doi.org/10.1186/s12874-019-0687-y |