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Key Amino Acid Substitution for Infection-Enhancing Activity-Free Designer Dengue Vaccines
Dengue is a globally important disease caused by four serotypes of dengue virus. Dengue vaccine development has been hampered by antigenic cross-reactivity among serotypes, which potentially causes antibody-dependent enhancement of infection and disease severity. Here we found that a single amino ac...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402262/ https://www.ncbi.nlm.nih.gov/pubmed/30826727 http://dx.doi.org/10.1016/j.isci.2019.02.012 |