Novel Synergistic Combination of Mitotic Arrest and Promotion of Apoptosis for Treatment of Pancreatic Adenocarcinoma

The BCL-2 family of proteins, including anti-apoptotic members BCL-2, BCL-XL and MCL-1, are part of a complex network that controls apoptosis. BH3-mimetics such as ABT-263 inhibit anti-apoptotic BCL-2 proteins and have been developed as potential cancer therapeutics. Aurora Kinase A (AKA) is over-ex...

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Detalles Bibliográficos
Autores principales: Duan, Zhijian, Chinn, Danielle, Tu, Mei-Juan, Zhang, Qian-Yu, Huynh, Jasmine, Chen, Justin, Mack, Philip, Yu, Ai-Ming, Kim, Edward J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402293/
https://www.ncbi.nlm.nih.gov/pubmed/30844579
http://dx.doi.org/10.1016/j.tranon.2019.01.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402293/
https://www.ncbi.nlm.nih.gov/pubmed/30844579
http://dx.doi.org/10.1016/j.tranon.2019.01.009

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