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Mapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription
Insulin (INS) synthesis and secretion from pancreatic β cells are tightly regulated; their deregulation causes diabetes. Here we map INS-associated loci in human pancreatic islets by 4C and 3C techniques and show that the INS gene physically interacts with the SYT8 gene, located over 300 kb away. Th...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402586/ https://www.ncbi.nlm.nih.gov/pubmed/21336277 http://dx.doi.org/10.1038/nsmb.1993 |