Induced aneuploidy in neural stem cells triggers a delayed stress response and impairs adult life span in flies

Studying aneuploidy during organism development has strong limitations because chronic mitotic perturbations used to generate aneuploidy usually result in lethality. We developed a genetic tool to induce aneuploidy in an acute and time-controlled manner during Drosophila development. This is achieve...

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Detalles Bibliográficos
Autores principales: Mirkovic, Mihailo, Guilgur, Leonardo G., Tavares, Alexandra, Passagem-Santos, Diogo, Oliveira, Raquel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402706/
https://www.ncbi.nlm.nih.gov/pubmed/30794535
http://dx.doi.org/10.1371/journal.pbio.3000016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402706/
https://www.ncbi.nlm.nih.gov/pubmed/30794535
http://dx.doi.org/10.1371/journal.pbio.3000016

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