Co-inhibitory T cell receptor KLRG1: human cancer expression and efficacy of neutralization in murine cancer models

BACKGROUND: KLRG1 is a lymphocyte co-inhibitory, or immune checkpoint, receptor expressed predominantly on late-differentiated effector and effector memory CD8+ T and NK cells. Targeting of KLRG1 neutralization in murine cancer models has not previously been reported. METHODS: We studied KLRG1 expre...

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Detalles Bibliográficos
Autores principales: Greenberg, Steven A., Kong, Sek Won, Thompson, Evan, Gulla, Stefano V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402715/
https://www.ncbi.nlm.nih.gov/pubmed/30858925
http://dx.doi.org/10.18632/oncotarget.26659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402715/
https://www.ncbi.nlm.nih.gov/pubmed/30858925
http://dx.doi.org/10.18632/oncotarget.26659

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