Cargando…

Global gene expression of histologically normal primary skin cells from BCNS subjects reveals “single-hit” effects that are influenced by rapamycin

Studies of dominantly heritable cancers enabled insights about tumor progression. BCNS is a dominantly inherited disorder that is characterized by developmental abnormalities and postnatal neoplasms, principally BCCs. We performed an exploratory gene expression profiling of primary cell cultures der...

Descripción completa

Detalles Bibliográficos
Autores principales:	Phatak, Amruta, Athar, Mohammad, Crowell, James A., Leffel, David, Herbert, Brittney-Shea, Bale, Allen E., Kopelovich, Levy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402716/ https://www.ncbi.nlm.nih.gov/pubmed/30858923 http://dx.doi.org/10.18632/oncotarget.26640

Ejemplares similares

Whole-Exome Sequencing Identified Two Novel Pathogenic Mutations in the PTCH1 Gene in BCNS
por: Pál, Margit, et al.
Publicado: (2023)

Mammalian Target of Rapamycin: Hitting the Bull's-Eye for Neurological Disorders
por: Chong, Zhao Zhong, et al.
Publicado: (2010)

A molecular signature of normal breast epithelial and stromal cells from Li-Fraumeni syndrome mutation carriers
por: Herbert, Brittney-Shea, et al.
Publicado: (2010)

Genome-wide identification, phylogeny, evolution, and expression patterns of MtN3/saliva/SWEET genes and functional analysis of BcNS in Brassica rapa
por: Miao, Liming, et al.
Publicado: (2018)

Early and delayed intervention with Rapamycin prevents NNK-induced lung adenocarcinoma in A/J mice
por: PATLOLLA, JAGAN M.R., et al.
Publicado: (2015)

Progeria, rapamycin and normal aging: recent breakthrough
por: Blagosklonny, Mikhail V.
Publicado: (2011)

Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention
por: Fan, Meiyun, et al.
Publicado: (2013)

Rapamycin for the aging skin
por: Blagosklonny, Mikhail V.
Publicado: (2019)

Normal Histology
por: Milroy, T. H.
Publicado: (1901)

Normal Histology
Publicado: (1911)

Normal Histology
Publicado: (1900)

Patched1 haploinsufficiency severely impacts intermediary metabolism in the skin of Ptch1(+/−)/ODC transgenic mice
por: Li, Changzhao, et al.
Publicado: (2019)

Author Correction: Patched1 haploinsufficiency severely impacts intermediary metabolism in the skin of Ptch1(+/−)/ODC transgenic mice
por: Li, Changzhao, et al.
Publicado: (2021)

Piersol's Normal Histology
Publicado: (1931)

Histology: Normal and Morbid
Publicado: (1899)

Histology: Normal and Morbid
Publicado: (1899)

The impact of telomeres and telomerase in cellular biology and medicine: it’s not the end of the story
por: Herbert, Brittney-Shea
Publicado: (2011)

Inhibiting Cycloxygenase and Ornithine Decarboxylase by Diclofenac and Alpha-Difluoromethylornithine Blocks Cutaneous SCCs by Targeting Akt-ERK Axis
por: Arumugam, Aadithya, et al.
Publicado: (2013)

PPARs as determinants of the estrogen receptor lineage: use of synthetic lethality for the treatment of estrogen receptor-negative breast cancer
por: Glazer, Robert I., et al.
Publicado: (2017)

The effect of static stretching on key hits and subjective fatigue in eSports
por: Okinaka, Miyono, et al.
Publicado: (2021)

The two-hit theory hits 50
por: Chernoff, Jonathan
Publicado: (2021)

Histology of the Blood, Normal and Pathological
por: Muir, Robert
Publicado: (1900)

Differential Roles of ERα and ERβ in Normal and Neoplastic Development in the Mouse Mammary Gland
por: Mehta, Rajendra G., et al.
Publicado: (2014)

Mixed Polymeric Micelles for Rapamycin Skin Delivery
por: Le Guyader, Guillaume, et al.
Publicado: (2022)

The two "hit" and multiple "hit" theories of carcinogenesis.
por: Ashley, D. J.
Publicado: (1969)

Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment
por: Martelli, Alberto M., et al.
Publicado: (2012)

Rapamycin reduces neuronal mutant huntingtin aggregation and ameliorates locomotor performance in Drosophila
por: Roth, Jonathan R., et al.
Publicado: (2023)

Immunoprevention of Basal Cell Carcinomas with Recombinant Hedgehog-interacting Protein
por: Vogt, Annika, et al.
Publicado: (2004)

Correlated metabolomic, genomic, and histologic phenotypes in histologically normal breast tissue
por: Sun, Xuezheng, et al.
Publicado: (2018)

Students’ Histology : A Course of Normal Histology for Students and Practitioners of Medicine
Publicado: (1899)

All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype
por: Pellegrini, Camilla, et al.
Publicado: (2015)

Rapamycin downregulates α-klotho in the kidneys of female rats with normal and reduced renal function
por: Espartero, Azahara, et al.
Publicado: (2023)

A Hit, a Hit—A Very Palpable Hit: Mild TBI and the Development of Epilepsy
por: Danzer, Steve C.
Publicado: (2019)

P1674: CLINICAL IMPACT OF NON-ADHERENCE TO HIT GUIDELINES: A DOUBLE HIT IN HIT
por: Al Raizah, A., et al.
Publicado: (2022)

Lab manual of normal oral histology /
por: Riviere, Holliston L.
Publicado: (2000)

Atlas of Normal Histology. Sixth Edition
por: Chang, James
Publicado: (1989)

A Manual of Normal Histology and Organography
Publicado: (1907)

Micro-Photographs in Histology—Normal and Pathological
Publicado: (1876)

Micro Photographs in Histology, Normal and Pathological
Publicado: (1876)

Micro-Photographs in Histology, Normal and Pathological
Publicado: (1876)

Cannot write session to /tmp/vufind_sessions/sess_g6s7oi5tm6cgt3a7m43dee2rjs