State transitions in the substantia nigra reticulata predict the onset of motor deficits in models of progressive dopamine depletion in mice

Parkinson’s disease (PD) is a progressive neurodegenerative disorder whose cardinal motor symptoms are attributed to dysfunction of basal ganglia circuits under conditions of low dopamine. Despite well-established physiological criteria to define basal ganglia dysfunction, correlations between indiv...

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Detalles Bibliográficos
Autores principales: Willard, Amanda M, Isett, Brian R, Whalen, Timothy C, Mastro, Kevin J, Ki, Chris S, Mao, Xiaobo, Gittis, Aryn H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402832/
https://www.ncbi.nlm.nih.gov/pubmed/30839276
http://dx.doi.org/10.7554/eLife.42746

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402832/
https://www.ncbi.nlm.nih.gov/pubmed/30839276
http://dx.doi.org/10.7554/eLife.42746

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