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Somatic mutations in early metazoan genes disrupt regulatory links between unicellular and multicellular genes in cancer
Extensive transcriptional alterations are observed in cancer, many of which activate core biological processes established in unicellular organisms or suppress differentiation pathways formed in metazoans. Through rigorous, integrative analysis of genomics data from a range of solid tumors, we show...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402835/ https://www.ncbi.nlm.nih.gov/pubmed/30803482 http://dx.doi.org/10.7554/eLife.40947 |