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Immunoglobulin deposition on biomolecule corona determines complement opsonisation efficiency of preclinical and clinical nanoparticles
Deposition of complement factors (opsonisation) on nanoparticles may promote clearance from the blood by macrophages and trigger proinflammatory responses, but the mechanisms regulating the efficiency of complement activation are poorly understood. We previously demonstrated that opsonisation of sup...
Autores principales: | Vu, Vivian P., Gifford, Geoffrey B., Chen, Fangfang, Benasutti, Halli, Wang, Guankui, Groman, Ernest V., Scheinman, Robert, Saba, Laura, Moghimi, Seyed Moein, Simberg, Dmitri |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402998/ https://www.ncbi.nlm.nih.gov/pubmed/30643271 http://dx.doi.org/10.1038/s41565-018-0344-3 |
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