Next-Generation Sequencing of PTGS Genes Reveals an Increased Frequency of Non-synonymous Variants Among Patients With NSAID-Induced Liver Injury

Purpose: The etiopathogenesis of drug-induced liver injury (DILI) is still far from being elucidated. This study aims to the study of genetic variations in DILI, related to the drug target, and specifically in the genes coding for the cyclooxygenase enzymes. Methods: By using Next-generation Sequenc...

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Detalles Bibliográficos
Autores principales: Lucena, María Isabel, García-Martín, Elena, Daly, Ann K., Blanca, Miguel, Andrade, Raúl J., Agúndez, José A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403122/
https://www.ncbi.nlm.nih.gov/pubmed/30873208
http://dx.doi.org/10.3389/fgene.2019.00134

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403122/
https://www.ncbi.nlm.nih.gov/pubmed/30873208
http://dx.doi.org/10.3389/fgene.2019.00134

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