Cargando…

Next-Generation Sequencing of PTGS Genes Reveals an Increased Frequency of Non-synonymous Variants Among Patients With NSAID-Induced Liver Injury

Purpose: The etiopathogenesis of drug-induced liver injury (DILI) is still far from being elucidated. This study aims to the study of genetic variations in DILI, related to the drug target, and specifically in the genes coding for the cyclooxygenase enzymes. Methods: By using Next-generation Sequenc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lucena, María Isabel, García-Martín, Elena, Daly, Ann K., Blanca, Miguel, Andrade, Raúl J., Agúndez, José A. G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Genetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403122/ https://www.ncbi.nlm.nih.gov/pubmed/30873208 http://dx.doi.org/10.3389/fgene.2019.00134

Ejemplares similares

A Meta-Analysis of PTGS1 and PTGS2 Polymorphisms and NSAID Intake on the Risk of Developing Cancer
por: Nagao, Mai, et al.
Publicado: (2013)

Evaluation of Glycosylated PTGS2 in Colorectal Cancer for NSAIDS-Based Adjuvant Therapy
por: Venè, Roberta, et al.
Publicado: (2020)

Synonymous Variant in the CHM Gene Causes Aberrant Splicing in Choroideremia
por: da Palma, Mariana Matioli, et al.
Publicado: (2020)

Systematic errors in annotations of truncations, loss-of-function and synonymous variants
por: Vihinen, Mauno
Publicado: (2023)

Predicting Functional Effects of Synonymous Variants: A Systematic Review and Perspectives
por: Zeng, Zishuo, et al.
Publicado: (2019)

The Downregulation of PTGS2 Mediated by ncRNAs is Tightly Correlated with Systemic Sclerosis-Interstitial Lung Disease
por: Xu, Zhixiao, et al.
Publicado: (2022)

Expression of Transcript Variants of PTGS1 and PTGS2 Genes among Patients with Chronic Rhinosinusitis with Nasal Polyps
por: Pietruszewska, Wioletta, et al.
Publicado: (2021)

Estimating Allele Frequency from Next-Generation Sequencing of Pooled Mitochondrial DNA Samples
por: Wang, Tao, et al.
Publicado: (2011)

A Comprehensive Analysis and Splicing Characterization of Naturally Occurring Synonymous Variants in the ATP7B Gene
por: Zhou, Xiaoying, et al.
Publicado: (2021)

Frequencies of 23 Functionally Significant Variant Alleles Related with Metabolism of Antineoplastic Drugs in the Chilean Population: Comparison with Caucasian and Asian Populations
por: Roco, Ángela, et al.
Publicado: (2012)

Editorial: NSAIDs Pharmacogenomics
por: Agúndez, José A. G., et al.
Publicado: (2021)

Next generation genetics
por: Fenger, Mogens
Publicado: (2014)

Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer
por: Cox, D G, et al.
Publicado: (2004)

Bioinformatics Tools and Databases to Assess the Pathogenicity of Mitochondrial DNA Variants in the Field of Next Generation Sequencing
por: Bris, Céline, et al.
Publicado: (2018)

SeqVItA: Sequence Variant Identification and Annotation Platform for Next Generation Sequencing Data
por: Dharanipragada, Prashanthi, et al.
Publicado: (2018)

Identification of an Endoglin Variant Associated With HCV-Related Liver Fibrosis Progression by Next-Generation Sequencing
por: About, Frédégonde, et al.
Publicado: (2019)

Case report: A novel heterozygous synonymous variant in deep exon region of NIPBL gene generating a non-canonical splice donor in a patient with cornelia de lange syndrome
por: Shi, Meizhen, et al.
Publicado: (2022)

FCERI and Histamine Metabolism Gene Variability in Selective Responders to NSAIDS
por: Amo, Gemma, et al.
Publicado: (2016)

Impact of Next Generation Sequencing in Unraveling the Genetics of 1036 Spanish Families With Inherited Macular Dystrophies
por: Del Pozo-Valero, Marta, et al.
Publicado: (2022)

Mammalian miRNA curation through next-generation sequencing
por: Brown, Miguel, et al.
Publicado: (2013)

Alteration of synonymous codon usage bias accompanies polyploidization in wheat
por: Tian, Geng, et al.
Publicado: (2022)

Next Generation Sequencing Identify Rare Copy Number Variants in Non-syndromic Patent Ductus Arteriosus
por: Chen, Bo, et al.
Publicado: (2020)

Identification of Variants Associated With Rare Hematological Disorder Erythrocytosis Using Targeted Next-Generation Sequencing Analysis
por: Kristan, Aleša, et al.
Publicado: (2021)

Intestinal PTGS2 mRNA Levels, PTGS2 Gene Polymorphisms, and Colorectal Carcinogenesis
por: Vogel, Lotte K., et al.
Publicado: (2014)

Novel association between TGFA, TGFB1, IRF1, PTGS2 and IKBKB single-nucleotide polymorphisms and occurrence, severity and treatment response of major depressive disorder
por: Bialek, Katarzyna, et al.
Publicado: (2020)

Asymmetric Somatic Hybridization Affects Synonymous Codon Usage Bias in Wheat
por: Xu, Wenjing, et al.
Publicado: (2021)

PredDSMC: A predictor for driver synonymous mutations in human cancers
por: Wang, Lihua, et al.
Publicado: (2023)

Application of Next Generation Sequencing for personalized medicine for sudden cardiac death
por: Morini, Elena, et al.
Publicado: (2015)

Analysis of chronic kidney disease patients by targeted next-generation sequencing identifies novel variants in kidney-related genes
por: Alaamery, Manal, et al.
Publicado: (2022)

Targeted next-generation sequencing for genetic variants of left ventricular mass status among community-based adults in Taiwan
por: Fan, Hsien-Yu, et al.
Publicado: (2023)

Applications for next-generation sequencing in fish ecotoxicogenomics
por: Mehinto, Alvine C., et al.
Publicado: (2012)

The Use of Next-Generation Sequencing in Movement Disorders
por: Krebs, Catharine E., et al.
Publicado: (2012)

Statistics for Next Generation Sequencing – Meeting Report
por: Wu, Hao, et al.
Publicado: (2012)

Case Report: Prenatal Whole-Exome Sequencing to Identify a Novel Heterozygous Synonymous Variant in NIPBL in a Fetus With Cornelia de Lange Syndrome
por: Qiao, Fengchang, et al.
Publicado: (2021)

Next-Generation Sequencing Analysis Reveals Novel Pathogenic Variants in Four Chinese Siblings With Late-Infantile Neuronal Ceroid Lipofuscinosis
por: Ren, Xiao-Tun, et al.
Publicado: (2019)

Next-Generation Sequencing for Binary Protein–Protein Interactions
por: Suter, Bernhard, et al.
Publicado: (2015)

Next Generation Sequencing Methods for Diagnosis of Epilepsy Syndromes
por: Dunn, Paul, et al.
Publicado: (2018)

Targeted Next-Generation Sequencing in the Diagnosis of Facial Dysostoses
por: Bukowska-Olech, Ewelina, et al.
Publicado: (2020)

Next-generation development and application of codon model in evolution
por: Gupta, Manoj Kumar, et al.
Publicado: (2023)

NSAID-induced reactions: classification, prevalence, impact, and management strategies
por: Blanca-Lopez, Natalia, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_cm1tkse0gvslobi3b4f4mlgfp0