T Cell Receptor (TCR)-Induced PLC-γ1 Sumoylation via PIASxβ and PIAS3 SUMO E3 Ligases Regulates the Microcluster Assembly and Physiological Function of PLC-γ1

The SUMO modification system plays an important role in T cell activation, yet how sumoylation regulates TCR-proximal signaling remains largely unknown. We show here that Phospholipase C-γ1 (PLC-γ1) is conjugated by SUMO1 at K54 and K987 upon TCR stimulation and that K54 sumoylation is pivotal for P...

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Detalles Bibliográficos
Autores principales: Wang, Qi-Long, Liang, Jia-Qi, Gong, Bei-Ni, Xie, Ji-Ji, Yi, Yu-Ting, Lan, Xin, Li, Yingqiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403162/
https://www.ncbi.nlm.nih.gov/pubmed/30873169
http://dx.doi.org/10.3389/fimmu.2019.00314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403162/
https://www.ncbi.nlm.nih.gov/pubmed/30873169
http://dx.doi.org/10.3389/fimmu.2019.00314

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