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Pyruvate-depleting conditions induce biofilm dispersion and enhance the efficacy of antibiotics in killing biofilms in vitro and in vivo

The formation of biofilms is a developmental process initiated by planktonic cells transitioning to the surface, which comes full circle when cells disperse from the biofilm and transition to the planktonic mode of growth. Considering that pyruvate has been previously demonstrated to be required for...

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Detalles Bibliográficos
Autores principales: Goodwine, James, Gil, Joel, Doiron, Amber, Valdes, Jose, Solis, Michael, Higa, Alex, Davis, Stephen, Sauer, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403282/
https://www.ncbi.nlm.nih.gov/pubmed/30842579
http://dx.doi.org/10.1038/s41598-019-40378-z