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Pyruvate-depleting conditions induce biofilm dispersion and enhance the efficacy of antibiotics in killing biofilms in vitro and in vivo
The formation of biofilms is a developmental process initiated by planktonic cells transitioning to the surface, which comes full circle when cells disperse from the biofilm and transition to the planktonic mode of growth. Considering that pyruvate has been previously demonstrated to be required for...
Autores principales: | Goodwine, James, Gil, Joel, Doiron, Amber, Valdes, Jose, Solis, Michael, Higa, Alex, Davis, Stephen, Sauer, Karin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403282/ https://www.ncbi.nlm.nih.gov/pubmed/30842579 http://dx.doi.org/10.1038/s41598-019-40378-z |
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