A method of predicting the in vitro fibril formation propensity of Aβ40 mutants based on their inclusion body levels in E. coli

Overexpression of recombinant proteins in bacteria may lead to their aggregation and deposition in inclusion bodies. Since the conformational properties of proteins in inclusion bodies exhibit many of the characteristics typical of amyloid fibrils. Based on these findings, we hypothesize that the ra...

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Detalles Bibliográficos
Autores principales: Sanagavarapu, Kalyani, Nüske, Elisabeth, Nasir, Irem, Meisl, Georg, Immink, Jasper N., Sormanni, Pietro, Vendruscolo, Michele, Knowles, Tuomas P. J., Malmendal, Anders, Cabaleiro-Lago, Celia, Linse, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403284/
https://www.ncbi.nlm.nih.gov/pubmed/30842594
http://dx.doi.org/10.1038/s41598-019-39216-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403284/
https://www.ncbi.nlm.nih.gov/pubmed/30842594
http://dx.doi.org/10.1038/s41598-019-39216-z

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