Early overnutrition reduces Pdx1 expression and induces β cell failure in Swiss Webster mice

Childhood obesity and early rapid growth increase the risk for type 2 diabetes. Such early overnutrition can be modeled in mice by reducing litter size. We investigated the effects of early overnutrition and increased dietary fat intake on β cell function in Swiss Webster mice. On a moderate-fat die...

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Detalles Bibliográficos
Autores principales: Glavas, Maria M., Hui, Queenie, Tudurí, Eva, Erener, Suheda, Kasteel, Naomi L., Johnson, James D., Kieffer, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403421/
https://www.ncbi.nlm.nih.gov/pubmed/30842440
http://dx.doi.org/10.1038/s41598-019-39177-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403421/
https://www.ncbi.nlm.nih.gov/pubmed/30842440
http://dx.doi.org/10.1038/s41598-019-39177-3

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