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Early overnutrition reduces Pdx1 expression and induces β cell failure in Swiss Webster mice
Childhood obesity and early rapid growth increase the risk for type 2 diabetes. Such early overnutrition can be modeled in mice by reducing litter size. We investigated the effects of early overnutrition and increased dietary fat intake on β cell function in Swiss Webster mice. On a moderate-fat die...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403421/ https://www.ncbi.nlm.nih.gov/pubmed/30842440 http://dx.doi.org/10.1038/s41598-019-39177-3 |