Polymer Nanocoating of Amorphous Drugs for Improving Stability, Dissolution, Powder Flow, and Tabletability: The Case of Chitosan-Coated Indomethacin

[Image: see text] As a result of its higher molecular mobility, the surface of an amorphous drug can grow crystals much more rapidly than the bulk, causing poor stability and slow dissolution of drug products. We show that a nanocoating of chitosan (a pharmaceutically acceptable polymer) can be depo...

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Detalles Bibliográficos
Autores principales: Li, Yuhui, Yu, Junguang, Hu, Shenye, Chen, Zhenxuan, Sacchetti, Mark, Sun, Changquan Calvin, Yu, Lian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404105/
https://www.ncbi.nlm.nih.gov/pubmed/30668120
http://dx.doi.org/10.1021/acs.molpharmaceut.8b01237

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404105/
https://www.ncbi.nlm.nih.gov/pubmed/30668120
http://dx.doi.org/10.1021/acs.molpharmaceut.8b01237

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